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A range of sophisticated systems catering to clarification & purification of biological process fluids. These systems are available as completely automated / semi-automatic / manual-based with scalability to match individual requirement and a host of customer-friendly features like Sanitization & SIP as per cGMP guidelines.
The unit is backed by comprehensive documentation to support validation requirements.
Principle Involved
The system operates on the principle of depth filtration techniques that remove contaminants in Downstream Process Fluids, based on mechanical removal and electrokinetic adsorption. The system incorporates CUNO Zeta plus filter of various grades which are designed for specific applications.
Applications
- Clarification of cell culture process fluids.
- Clarification of cell lysates.
- Clarification of highly viscous biomass.
- Removal of contaminating host cell DNA / color from process fluids.
- Clarification of toxoid broths in vaccine manufacture.
- Protection or replacement of TFF (Tangential Flow Filtration) systems.
- Pre-filtration to protect chromatography columns & sterile membrane filters.
- Clarification of plasma derived biologicals.
- Removal of contaminating viruses & lipids from therapeutics & blood products.
Also cater to other critical applications
- Sterile vent for holding & mixing tanks.
- Sterile filtration of air & nitrogen.
- Protection of Expensive Chromatography Columns by Membrane Filters.
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Depth Filtration System in
Downstream
Purification |
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